Saliva has serous and / or mucous types is secreted from major and minor salivary glands to oral cavity through salivary ducts. Saliva plays an important role for helping digestion of food, providing the integrity and continuity of the oral mucosa. Its functions include soaking and lubricating the foods, moistening of the upper part of the digestive tract, allowing the stimulation of the taste bud receptors with water-insoluble nutrients and etc. The secretion content involves digestive enzymes for carbohydrate and fat, important proteins and enzymes against infectious agents for the oral cavity protection . Changes in the amount and composition of saliva negatively affects people's quality of life. Parotid gland, one of the major salivary glands, contributes significantly by providing approximately ¼ of saliva with the serous secretion and content of the digestive enzymes, such as α-amylase, peroxidase, lysozyme, antimicrobial effective proteins such as cystatin and histatin, and secreting immunoglobulin A. Diabetes Mellitus is a metabolic disorder characterized by hyperglycemia.It may cause complications in many systems, organs and tissues. Parotid tissue is involved in the tissues affected by diabetes.
Keywords: Diabetes, IGF 1, INS-R, Lipid Accumulation, Parotid