Batman Universitesi Yasam Bilimleri Dergisi
Cilt 5, Sayı 1  Ocak-Haziran 2015  (ISSN: 2147-4877, E-ISSN: 2459-0614)

NO Makale Adı
1433860198 Evaluation of Small Dense LDL, Endothelin-1 And Lipocalin-2 Levels in Obese Children

The high prevalence of childhood obesity and related health consequences have received increasing attention in medical studies and health policies. It is emphasized that abdominal obesity and the level of small dense LDL (sdLDL) are related each other and, the level of ET-1 have increasing in obese population. Lipocalin-2 (LCN-2) plays a role in thermoregulation and is associated with obesity. Therefore, we aim to evaluate sdLDL, ET-1 and Lip-2 levels in obese children. Our study included 51 obese children and 40 healthy controls aged 6-15 years. Obesity was defined as a body mass index (BMI) ≥ 95th percentile for age and gender. Serum LCN–2, plasma endothelin–1 were measured by enzyme-linked immunosorbent assays, and the measurement of sdLDL were determined using the LDL measurement kit in autoanalyzer followed by obtaining supernatant. The height, weight and BMI of obese children was significantly higher than that of the control group (p<0,05). When the two groups were compared; there was no statistically significant difference among sdLDL, ET-1 and LCN-2 levels (p>0,05). Lip-2 levels were found to be statistically significantly higher in the obese girls compared to obsese boys (p<0,05). We suggest that clarification of the increased lip-2 level of girls with future experimental and cellular studies may contribute to the understanding of the impact of obesity on gender.